Last Update: Jun 23, 2026 A Randomized Double-blind, Placebo-controlled, Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis [Lp(a)FRONTIERS CAVS] ClinicalTrials.gov Identifier: [NCT05646381](https://clinicaltrials.gov/ct2/show/NCT05646381) Novartis Reference Number:CTQJ230A12203 [See if you Pre-qualify](#trial-eligibility "See if you Pre-qualify") All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the use(s) under investigation. ## Study Description The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis. Condition Aortic Stenosis Phase Phase2 Overall Status Recruiting Number of Participants502 Start Date Mar 07, 2024 Completion Date Mar 12, 2030 Gender All Age(s) 50 Years - 80 Years (Adult, Older Adult) ## Interventions Drug ### Matching placebo Matching placebo Drug ### Pelacarsen (TQJ230) 80mg Pelacarsen (TQJ230) 80mg ## Eligibility Criteria Inclusion Criteria: \* Male and female ≥50 to \\<80 years of age at Screening Part II \* Lp(a) ≥175 nmol/L at the screening visit, measured at the Central laboratory \* Mild or moderate calcific aortic valve stenosis \* At the randomization visit, participant must be optimally treated for existing CV risk factors Exclusion Criteria: \* Severe calcific aortic valve stenosis \* Uncontrolled hypertension \* History of malignancy of any organ system \* History of hemorrhagic stroke or other major bleeding \* Platelet count ≤ LLN \* Active liver disease or hepatic dysfunction \* Significant kidney disease \* Pregnant or nursing women Other 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