Last Update: Aug 21, 2026 A Multicenter, Prospective, Study to Evaluate the Impact of Modifying the Validated Psoriasis Epidemiology Screening Tool (PEST) on the Potential Diagnosis of Psoriatic Arthritis in Adult Patients With Moderate-to-severe Plaque Psoriasis in Canada ("ScreenX") ClinicalTrials.gov Identifier: [NCT06382051](https://clinicaltrials.gov/ct2/show/NCT06382051) Novartis Reference Number:CAIN457ACA06 [See if you Pre-qualify](#trial-eligibility "See if you Pre-qualify") All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the use(s) under investigation. ## Study Description The purpose of this study is to assess the impact of adding two questions and pictures to the validated PEST on the potential diagnosis of PsA in participants with moderate-to-severe plaque PsO in Canada. Patients will be enrolled in the study for up to 120 days and will be asked to fill-out a PsA screening questionnaire at their first dermatologist visit. Patients screening positive for PsA will have a second visit with a rheumatologist where a full PsA diagnosis assessment will be performed. A remote 'end of study' (EOS) visit will be conducted by the dermatologist to document the patient's biologic Disease-Modifying Antirheumatic Drugs (bDMARDs) treatment choice and status. Condition Plaque Psoriasis, Psoriatic Arthritis Phase Na Overall Status Recruiting Number of Participants502 Start Date Jan 23, 2025 Completion Date Dec 31, 2026 Gender All Age(s) 18 Years - (Adult, Older Adult) ## Interventions Diagnostic_test ### PEST Screening group PEST Screening group ## Eligibility Criteria Key inclusion criteria: 1\. Moderate-to-severe plaque PsO patients who are candidates for bDMARDs, according to physician's clinical judgement at the time of patient enrollment. 2\. Adult patients at the time of informed consent signature 3\. Patients able to understand and willing to comply with protocol requirements, instructions, and restrictions 4\. Residents of Canada Key exclusion criteria: 1\. Patients who have previously screened positive for PsA through PEST. 2\. Patients who have been diagnosed with PsA. 3\. Patients who have been diagnosed with inflammatory arthritis unrelated to PsA (rheumatoid arthritis, reactive arthritis, enteropathic arthritis, axial spondyloarthritis) 4\. Patients treated with a bDMARD for moderate-to-severe plaque PsO or any other medical condition within the last 6 months prior to patient enrollment. Canada #### Novartis Investigative Site Recruiting Calgary,Alberta,T2j 7e1,Canada #### Novartis Investigative Site Recruiting Toronto,Ontario,M4a2s8,Canada #### Novartis Investigative Site Recruiting Ottawa,Ontario,K2a 3z3,Canada #### Novartis Investigative Site Recruiting Québec,Quebec,G1w 4r4,Canada #### Novartis Investigative Site Recruiting Montreal,Quebec,H1t 2m4,Canada #### Novartis Investigative Site Recruiting London,Ontario,N6g 0w7,Canada #### Novartis Investigative Site Recruiting London,Ontario,N6a 5r9,Canada #### Novartis Investigative Site Recruiting Greater Sudbury,Ontario,P3c 1x8,Canada #### Novartis Investigative Site Recruiting Barrie,Ontario,L4m 6l2,Canada #### Novartis Investigative Site Recruiting Edmonton,Alberta,T6g 2c8,Canada #### Novartis Investigative Site Recruiting Edmonton,Alberta,T5j 3s9,Canada #### Novartis Investigative Site Recruiting Verdun,Quebec,H4g 3e7,Canada #### Novartis Investigative Site Recruiting Montreal,Quebec,H4a 3t2,Canada #### Novartis Investigative Site Recruiting Toronto,Ontario,M5s 1b6,Canada #### Novartis Investigative Site Recruiting Winnipeg,Manitoba,R3c 0n2,Canada #### Novartis Investigative Site Recruiting Hamilton,Ontario,L8n 1v6,Canada #### Novartis Investigative Site Recruiting Montreal,Quebec,H1y 3l1,Canada #### Novartis Investigative Site Recruiting Surrey,British Columbia,V3r 6a7,Canada #### Novartis Investigative Site Recruiting Saskatoon,Saskatchewan,S7k0h6,Canada #### Novartis Investigative Site Recruiting Saskatoon,Saskatchewan,S7k 2c1,Canada #### Novartis Investigative Site Recruiting Ste-Foy,Quebec,G1v 4g2,Canada #### Novartis Investigative Site Recruiting Québec,Quebec,G1v 4x7,Canada #### Novartis Investigative Site Recruiting Waterloo,Ontario,N2j 1c4,Canada #### Novartis Investigative Site Recruiting Richmond Hill,Ontario,L4c 9m7,Canada #### Novartis Investigative Site Recruiting Markham,Ontario,L3r 2c7,Canada #### Novartis Investigative Site Recruiting Hamilton,Ontario,L8p4b4,Canada #### Novartis Investigative Site Recruiting Hamilton,Ontario,L8j 0g5,Canada #### Novartis Investigative Site Recruiting Fredericton,New Brunswick,E3b 1g9,Canada #### Novartis Investigative Site Recruiting Kelowna,British Columbia,V1w 4v5,Canada #### Novartis Investigative Site Recruiting Stoney Creek,Ontario,L8g 1h1,Canada ## Worldwide Contacts If the location of your choosing does not feature any contact detail, please reach out using the information below. #### Novartis Pharmaceuticals Phone: [ +41613241111](tel:+41613241111) Email: #### Novartis Pharmaceuticals Phone: - Email: -