Senior Expert, Chemical Pharmaceutical Profiling (CPP) Project Leader

Novartis is looking for a highly motivated, experienced, and team-oriented individual for an opportunity to lead multiple projects for assessing the developability of new chemical entities (NCE's) destined for various routes of delivery and to participate in cross-functional teams to select molecules that can be successfully developed. The ideal individual for this role should exhibit exceptional leadership skills and possess a vision for creating an innovative discovery pharmaceutics support team working closely with pharmacokinetic, chemistry, tox, and pharmacology colleagues. The role includes using conventional and high throughput technologies to provide formulation data with an emphasis on solid state profiling, while utilizing very small amounts of drug substance. A special emphasis on early assessment of physiochemical properties and excipient compatibility will be required. The individual will also guide a team who will develop formulations for pharmacology and toxicology studies and identify a formulation principle for first in human "proof of concept" studies using small amount of material and faster turnaround of time to expedite molecule faster into clinic working with CRO/CMO’s and internal teams. This position requires strong technical skills in physical chemical characterization, formulation, and biopharmaceutics as well as experience in selecting salt, co-crystal and polymorph screening processes. The candidate should be an expert in preclinical drug development and influencing project leader who can influence his/her research teams to ensure the right biopharmaceutical properties are present in given NCE prior to selection for development. The individual should possess strong knowledge of IVIVCs, G+ modeling, and various other early-stage development tools. The candidate will work very closely with novel drug delivery/innovation, digital, and early phase excellence teams within research and development line functions.