Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events

Inclusion Criteria:

- Male or female ≥18 years or ≤80 years of age at signing of informed consent.

- Fasting LDL-C local lab value at the Screening Visit of either i) ≥100 mg/dL if on
statin therapy but not on a maximally tolerated statin therapy; ii) ≥150 mg/dL if
statin naive and without documented statin intolerance; or iii) ≥70 mg/dL if on a
stable (≥4 weeks) dose of maximally tolerated statin therapy or if statin
intolerant.

- Participants may be pre-identified based on a CCTA or an invasive angiography that
is performed as part of standard of care within 12 months prior to the participant's
Screening Visit demonstrating:

- Presence of coronary artery plaque with visual diameter stenosis <50% or

- Coronary artery plaque with visual artery stenosis >50% but Fractional Flow Reserve
(FFR) >0.8 by special wire measurement (CCTA or coronary angiography)

- Fasting LDL-C local lab value ≥70 mg/dL at the assessment performed during the
Statin Optimization Period 3 Visit for participants going through the Statin
Optimization Period.

- Participants having Non-Obstructive Coronary Artery (NOCA)* confirmed by CCTA with
FFRct >0.8 and CT-adapted Leaman score >5** or coronary artery plaque with visual
diameter stenosis >50% but with FFRct >0.8 and CT-adapted Leaman score >5 without
previous cardiovascular events.

*=NOCA is defined as the presence of coronary artery plaque with visual diameter
stenosis <50%.

**=CT-adapted Leaman score, which includes information on lesion localization,
plaque composition, degree of stenosis by CCTA is demonstrated to be an independent
long-term predictor of hard cardiac events.

- A standard of care CCTA may serve as the study baseline CCTA scan if it is performed
within 3 months prior to the participant's Screening Visit and meets the inclusion
criteria of FFRct >0.8 and CT-adapted Leaman score >5, which will be assessed by the
Imaging Core Lab.

- At the Baseline Visit, participants must be on a stable (≥4 weeks) dose of maximally
tolerated statin therapy. Participants not on maximally tolerated statin therapy and
who do not have documented statin intolerance can be screened but must enter the
study via a Statin Optimization Period.

Exclusion Criteria:

- Previous cardiovascular events history including myocardial infarction (MI), or
prior coronary revascularization [percutaneous coronary intervention (PCI) or
coronary artery bypass graft (CABG)].

- Planned revascularization (PCI) or (CABG).

- Previous cerebrovascular events including:

- Prior ischemic stroke thought not to be caused by atrial fibrillation, valvular
heart disease or mural thrombus.

- History of prior percutaneous or surgical carotid artery revascularization.

- History of Peripheral Artery Disease (PAD):

- Prior documentation of a resting ankle-brachial index <0.85.

- History of prior percutaneous or surgical revascularization of an iliac, femoral, or
popliteal artery.

- Prior non-traumatic amputation of a lower extremity due to peripheral artery
disease.

- Cardiac disorders, including any of the following:

- Clinically significant cardiac arrhythmias (e.g., ventricular tachycardia, atrial
fibrillation) within 3 months prior to randomization that is not controlled by
medication or via ablation at the time of the Screening Visit.

- Complete left bundle branch block, high-grade atrioventricular (AV) block (e.g.,
bifascicular block, Mobitz type II and third-degree AV block) prior to
randomization.

- NOCA participant who was prescreened by the Investigator with visual diameter
stenosis >50% but FFR <0.8.

- Contraindication for CCTA (e.g., allergic reactions to the contrast dye) or CCTA not
meeting entry standards after two attempts during the Baseline CCTA Visit as
assessed by the Imaging Core Lab.

- Pacemaker or implantable cardioverter-defibrillator (ICD) in situ.

- Systolic Left Ventricle Ejection Fraction <30% at the Screening Visit.

- Uncontrolled severe hypertension: systolic blood pressure >180 mmHg or diastolic
blood pressure >110 mmHg prior to randomization (assessed at the Screening Visit)
despite antihypertensive therapy.

- Heart failure New York Heart Association (NYHA) class III or class IV at the
Screening Visit.

- Renal insufficiency (eGFR <30 mL/min/1.73m2) as measured by the Modification of Diet
in Renal Disease (MDRD) formula at the Screening Visit and at the Statin
Optimization 3 Visit.

- Active liver disease defined as any known current infectious, neoplastic, or
metabolic pathology of the liver at the Screening Visit. Participants who enter the
Statin Optimization Period must have AST and ALT ≤3x ULN (as defined by local
laboratory reference ranges collected at the Screening Visit) and reported by the
Statin Optimization Telephone Visit 1 to be allowed to continue in the Statin
Optimization Period.