Active Clinical Trials

Clinical trials are at the heart of our work to bring innovative medicines to people with a particular disease or condition. Learn more about the active studies conducted by Novartis including opportunities to get involved.

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Study title Condition Phase Location NCT ID

A Phase Ib/II Open-label Study of AMO959 With Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI in Adult Participants With PSMA-positive mCRPC

 		PSMA-positive Metastatic Castration Resistant Prostate Cancer (mCRPC) With Prior Exposure to One Prior ARPI Who Are Candidates for Taxane-based Chemotherapy Phase1, Phase2 Australia NCT07226986

A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

 		Atrial Fibrillation Phase2 Canada
China
Germany
Netherlands
Singapore
United Kingdom
United States
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 NCT07217067

Phase 2a Study to Assess the Efficacy,Safety and Tolerability of GIA632 in Adult Participants With Moderate to Severe Atopic Dermatitis

 		Atopic Dermatitis Phase2 Canada
Malaysia
Singapore
United States
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 NCT07220577

A Phase II Trial to Evaluate the Clinical Efficacy, Safety and Tolerability of MAS825 in Pediatric and Adult Participants With Still's Disease

 		Still´s Disease Phase2 Canada
United States 		NCT07203001

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

 		Alzheimer's Disease Phase2 Canada
United Kingdom
United States 		NCT07094516

Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

 		Small Cell Lung Carcinoma, Large Cell Neuroendocrine Carcinoma of the Lung, Neuroendocrine Prostate Cancer, Gastroenteropancreatic Neuroendocrine Carcinoma Phase1 Canada
South Korea
United States 		NCT07006727

EPIK-P4: A Phase II Single-arm Study to Assess the Efficacy, Safety and Pharmacokinetics of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum (PROS)

 		PIK3CA-related Overgrowth Spectrum (PROS) Phase2 Australia
Austria
Belgium
France
Germany
Italy
Spain
United States
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 NCT06997588

A First in Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of EDK060 in Adults With CMT1A.

 		Charcot-Marie-Tooth Disease, Type 1A Phase1 Canada NCT07140614

An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)

 		Progressive Metastatic Castrate Resistant Prostate Cancer Phase1, Phase2 Australia
Denmark
Malaysia
Poland
Singapore
United States
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 NCT07206056

Study of Efficacy and Safety of Ruxolitinib in Chinese Participants With Corticosteroid-refractory Chronic Graft vs. Host Disease

 		Graft vs. Host Disease, Chronic Graft vs. Host Disease, Corticosteroid-refractory Chronic Graft vs. Host Disease Phase4 China NCT06824103